WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Toxoplasmosis       ID:05145
C=132; O=3; E=0.19; R=15.56; rawP=0.0010; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000185338 NA SOCS1 suppressor of cytokine signaling 1 8651 ENSG00000185338
2  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906
3  ENSG00000127472 NA PLA2G5 phospholipase A2, group V 5322 ENSG00000127472


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=4; E=0.48; R=8.40; rawP=0.0013; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163251 NA FZD5 frizzled family receptor 5 7855 ENSG00000163251
2  ENSG00000116016 NA EPAS1 endothelial PAS domain protein 1 2034 ENSG00000116016
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906
4  ENSG00000168646 NA AXIN2 axin 2 8313 ENSG00000168646


Database:KEGG pathway       Name:Wnt signaling pathway       ID:04310
C=150; O=3; E=0.22; R=13.69; rawP=0.0014; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
2  ENSG00000163251 NA FZD5 frizzled family receptor 5 7855 ENSG00000163251
3  ENSG00000168646 NA AXIN2 axin 2 8313 ENSG00000168646


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=3; E=0.20; R=14.88; rawP=0.0011; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
2  ENSG00000111725 NA PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 5564 ENSG00000111725
3  ENSG00000185338 NA SOCS1 suppressor of cytokine signaling 1 8651 ENSG00000185338


Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=3; E=0.13; R=23.61; rawP=0.0003; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
2  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906
3  ENSG00000090376 NA IRAK3 interleukin-1 receptor-associated kinase 3 11213 ENSG00000090376


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=4; E=0.39; R=10.22; rawP=0.0007; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143507 NA DUSP10 dual specificity phosphatase 10 11221 ENSG00000143507
2  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
3  ENSG00000127472 NA PLA2G5 phospholipase A2, group V 5322 ENSG00000127472
4  ENSG00000130222 NA GADD45G growth arrest and DNA-damage-inducible, gamma 10912 ENSG00000130222


Database:KEGG pathway       Name:Arachidonic acid metabolism       ID:00590
C=59; O=2; E=0.09; R=23.21; rawP=0.0034; adjP=0.0064
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000127472 NA PLA2G5 phospholipase A2, group V 5322 ENSG00000127472
2  ENSG00000179593 NA ALOX15B arachidonate 15-lipoxygenase, type B 247 ENSG00000179593


Database:KEGG pathway       Name:Basal cell carcinoma       ID:05217
C=55; O=2; E=0.08; R=24.89; rawP=0.0030; adjP=0.0064
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163251 NA FZD5 frizzled family receptor 5 7855 ENSG00000163251
2  ENSG00000168646 NA AXIN2 axin 2 8313 ENSG00000168646


Database:KEGG pathway       Name:Taste transduction       ID:04742
C=52; O=2; E=0.08; R=26.33; rawP=0.0027; adjP=0.0064
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
2  ENSG00000158445 NA KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 3745 ENSG00000158445


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=2; E=0.10; R=20.13; rawP=0.0045; adjP=0.0076
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000111725 NA PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 5564 ENSG00000111725
2  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).